Arbeitsgruppe Endokrinologie

 

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Ausgewählte Publikationen der Abteilung zu thematischen Schwerpunkten

Endokrine Disruptoren

Wuttke W, Jarry H, Seidlova-Wuttke D.
Definition, classification and mechanism of action of endocrine disrupting chemicals. Hormones (Athens) 9:9-15.

Schlecht C, Klammer H, Frauendorf H, Wuttke W, Jarry H.
Pharmacokinetics and metabolism of benzophenone 2 in the rat. Toxicology. 2008 Mar 12;245(1-2):11-7

H. Jarry, C. Schlecht, H. Klammer, W. Wuttke
Praktische Bedeutung von endokrin aktiven Chemikalien. Internistische Praxis (2008/ Folge 1), Hans Marseille Verlag GmbH München

C. Schmutzler et al.,
Endocrine disruptors and the Thyroid Gland-A combined in Vitro and in Vivo Analysis of Potential New Biomarkers. Environmental health Perspectives, Dezember 2007, Vol. 115, Supplement 1, P 77-83

Schmutzler C, Bacinski A, Gotthardt I, Huhne K, Armbrugger P, Klammer H, Schlecht, C.,.
The UV filter benzophenone 2 interfeers with the thyroid hormone axis in the rat and is a potent in vitro inhibitor of human recombinant thyroid peroxidase, Endocrinology,148(6):2835-44, 2007

Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Kohrle J, Jarry H
Effects of a 5-day treatment with the UV-filter octyl,ethoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats. Toxicology, 238(2-3): 192-9, 2007

Wolfgang Wuttke
Multi-organic risk assessment of selected endocrine disruptors, www.credocluster.info , (Nov. 2006), page 5-6

Jarry, H.,  Christoffel, J.,  Rimoldi, G., Koch, L, Wuttke, W.
Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment, Toxicology, 205: 87-93, 2004

Seidlová-Wuttke, D., Jarry, H., Wuttke, W.
Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP)in uterus, vagina and bone, Toxicology, 205: 103-112, 2004

Schlecht, C., Klammer, H.,  Jarry, H.,  Wuttke, W.
Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats, Toxicology, 205: 123-130, 2004

Jarry, H., Gamer A., Wuttke W.
Effects of 5-day styrene inhalation on serum LH and testosterone levels and on hypothalamic and striatal aminoacid neurotransmitter concentrations in male rats.  Inhalation Toxicology, 16:209-215, 2004

Schlumpf, M., Jarry, H., Wuttke, W., Ma, R., Lichtensteiger, W.
Estrogenic activity and estrogen receptor ß binding of the UV filter 3-benzylidene camphor. Comparison with 4-methylbenzylidene camphor. Toxicology 199:109-120, 2004

Schlumpf M., Schmid, P., Durrer, S., Conscience, M., Maerkel, K., Henseler, M., Gruetter, M., Herzog, I., Reolon, S., Ceccatelli, R., Faass, O., Stutz, E., Jarry, H., Wuttke, W., Lichtensteiger, W.
Endocrine activity and
developmental toxicity of cosmetic UV filters – an update. Toxicology 205:113-122, 2004

Schmutzler, C., Hamann, I., Hofmann, P.J., Kovacs, G., Stemmler, L., Mentrup, B., Schomburg, L., Ambrugger, P., Grüters, A., Seidlova-Wuttke, D., Jarry, H., Wuttke, W, Köhrle, J.
Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney. Toxicology 205:95-102, 2004

Wuttke, W., Jarry, H., Becker, T., Schultens, A., Christoffel, V., Gorkow, C.,  Seidlová-Wuttke, D.
Phytoestrogens: Endocrine disrupters or replacement for hormone replacement therapy? Maturitas 44:S9-20, 2003

 

Pflanzliche Extrakte

Kapur P, Wuttke W, Seidlova-Wuttke D
The Cimicifuga racemosa special extract BNO 1055 prevents hot flashes in ovariectomized rats. Phytomedicine 2010 17:890-894

Kelly LA, O’Leary JJ, Seidlova-Wuttke D, Wuttke W, Norris LA.
Genistein alters coagulation gene expression in ovarietomised rats treated with phytoestrogens. Thrombosis and Haemostasis 2010

Ehrhard C, Wessels JT, Wuttke W, Seidlova-Wuttke D.
The effects of 20-OH-Ecdysone and 17ß-Estradiol in the skin of ovariectomized rats. Menopause 2010.

Seidlova-Wuttke D, Christel D, Kapur P, Nguyen BT, Jarry H, Wuttke W.
Beta-Ecdysone has bone protective but no estrogenic effects in ovariectomized rats. Phytomedicine. June 2010. [Epub ahead of print]

Stuermer EK, Sehmisch S, Rack T, Wenda E, Seidlova-Wuttke D, Tezval M, Wuttke W, Frosch KH, Stuermer KM.
Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat. Langenbecks Arch Surg. 2010 Feb; 395(2):163-72.

Kolios L, Hoerster AK, Sehmisch S, Malcherek MC, Rack T, Tezval M, Seidlova-Wuttke D, Wuttke W, Stuermer KM, Stuermer EK.
Do estrogen and alendronate improve metaphyseal fracture healing when applied as osteoporosis prophylaxis? Calcif Tissue Int. 2010 Jan;86(1):23-32.

  Kolios L, Schumann J, Sehmisch S, Rack T, Tezval M, Seidlova-Wuttke D, Frosch, KH, Stuermer K, Stuermer E.
Effects of Black Cohosh (Cimicifuga racemosa) and Estrogen on Metaphyseal Fracture Healing in the Early Stage of Osteoporosis in Ovariectomized Rats. Planta Med. 2010 Jan 26 (Epub ahead of print)

Kapur P, Wuttke W, Seidlova-Wuttke D (2010)
Beneficial effects of ß-Ecdysone on joint, epiphyseal cartilage tissue and trabecular bone in ovarectomized rats. Phytomedicine, 17: 350-355

Seidlová-Wuttke D, Ehrhardt C, Wuttke W (2010): Metabolic effects of 20-OH Ecdysone in ovarectomized rats. J of Steroid Biochem Mol Biol 119, (3-5): 121-126

Thielemann A, Wuttke W, Wuttke M, Seidlova-Wuttke D (2010): Comparison of urodynamic effects of phytoestrogens equol , puerarin and genistein with these of 17beta in ovariectomiezed rats. Exp Gerontol. 45(2) 129-137

 Wuttke W, Jarry H, Seidlova-Wuttke D.
Plant derived alternative treatments for the ageing male: facts and myths. Ageing Male 13:75-81

Seidlova-Wuttke D, Jarry H, Wuttke W (2009): Effects of Estradiolbenzoat (EB), Raloxifen (Ral) and an ethanolic extract of Cimicifuga racemosa (CR) in non classical estrogen regulated organs of ovariectomized rats. Planta Medica, 75, 1279-1285. 

Dana Seidlova-Wuttke, Hubertus Jarry, Wolfgang Wuttke
Effects
of Estradiolbenzoat (EB), Raloxifen (Ral) and an ethanolic extract of Cimicifuga racemosa (CR) in non classical estrogen regulated organs of ovariectomized rats. Planta Medica, 2009; 75: 1-7

Rachoń D, Menche A, Vortherms T, Seidlová-Wuttke D, Wuttke W.
Effects of dietary equol administration on the mammary gland in ovariectomized Sprague-Dawley rats. Menopause.
2008 Mar-Apr;15(2):340

Dominik Rachon, Tina Vortherms, Dana Seidlová-Wuttke, Wolfgang Wuttke
Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague–Dawley rats.  Maturitas 60 (2008) 209–215

Rachoń D, Vortherms T, Seidlová-Wuttke D, Jarry H, Wuttke W.
Dietary quercetin does not affect pituitary lutenizing hormone (LH) expression and has no uterotropic effects in ovariectomized Sprague-Dawley rats. Food Chem Toxicol. 2008 Feb;46(2):513-8. Epub 2007 Aug 29

W. Wuttke et al.,(NIH)
Safety and Benefit of Black cohosh (BC workshop manual), subm. to Nutrition Today, 2008

W. Wuttke, H. Jarry, D. Seidlová-Wuttke, T. Devyatchenko, O. Pogodin,
S.A. Levenets
Extrakte aus Mönchspfeffer (Vitex Agnus castus) Stellenwert der Therapie in der gynäkologischen Praxis.
Gyn. Endokrinologie, Springer Verlag
 2008 6:82-86

Seidlová-Wuttke D, Jarry H, Jäger Y, Wuttke W.
Bone development in female rats maintained with soy-free or soy-containing food as determined by computer-assisted tomography and serum bone markers. J Bone Miner Metab.
 2008;26(4):321-7.

Sehmisch, Stephan; Hammer, Frauke; Christoffel, Julie; Seidlova-Wuttke, Dana; Tezval Mohammed; Wuttke, Wolfgang; Stürmer, Klaus Michael; Stürmer, Ewa Klara
Comparison of the Phytohormone Genistein, Resveratrol and 8-Prenylnaringenin as Agents for Preventing Osteoporosis. Planta Med. 2008 Jun;74(8):794-801.

D. Seidlová-Wuttke, H. Jarry, Y. Jäger, W. Wuttke
Bone development in the female rats kept under soy-containing food as determined by computer tomographiy and by serum bone markers. Journal of Bone and Mineral Metabolism 2008, Vol. 26, No.4

Rachón D, Menche A, Vortherms T, Seidlová-Wuttke D, Wuttke W
Effects of dietary equol administration on the mammary gland in ovariectomized Sprague-Da3wley rats. Menopause. 2008 Mar-Apr; 15(2):340-5

Thelen P, Peter T, Hütermund A, Kaulfuß S, Seidlová-Wuttke D, Wuttke W, Ringert RH, Seseke F
Phytoestrogens from Belamcanda chinensis regulate the expression of steroid receptors and related cofactors in LNCaP prostate cancer cells. BJU Int, 2007, 100(1): 199-203

G. Rimoldi, J. Christoffel, D. Seidlová-Wuttke, H. Jarry, W. Wuttke
Effects of Chronic Genistein Treatment in Mammary Gland, Uterus and Vagina

Environmental health Perspectives, Dezember 2007, Vol. 115, Supplement 1, P 62-68

Rachoń D, Seidlová-Wuttke D, Vortherms T, Wuttke W.
Effects of dietary equol administration on ovariectomy induced bone loss in Sprague-Dawley rats. Maturitas. 2007 Nov 20;58(3):308-15. Epub 2007 Oct 24.

Rachón D, Vortherms T, Seidlová-Wuttke D, Wuttke W
Dietary daidzein and puerarin do not affect pituitary LH expression but exert uteritropic effects in ovariectomized rats. Maturitas. 2007 Jun 20; 57(2):161-70. Epub 2007 Jan 26

Rachon, D., Vortherms, T., Seidlová-Wuttke, D., Wuttke, W.
Effects of dietary equol on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats, Menopause 14, (5), 1-8, 2007, PMID: 17414092

Rachon D, Vortherms T, Seidlová-Wuttke D, Menche A, Wuttke W
Uterotropic effects of dietary equol administration in ovariectomized Sprague-Dawley rats. Climacteric, 10(5): 416-26, 2007

Jarry H, Strromeier S, Wuttke W, Nahrstedt A
Petasphenone, a phenol isolated from Cimicifuga racemosa, in vitro inhibits proliferation of the human prostate cancer cell line LNCaP. Planta Med, 73(2): 184-7, 2007

Wuttke, W., Jarry, H., Seidlová-Wuttke, D.
Cimicifuga racemosa extract for the treatment of climacteric complaints, J Endoc Reprod (India), 10, 2:106-110, 2006

Paul Thelen, F. Seseke, RH Ringert, Wolfgang Wuttke, Dana Seidlova-Wuttke,
Pharmacological potential of phytoestrogens in the treatment of prostate cancer, Urologie A, 45(2): 195-6, 197-201, 2006

Jarry, H., Thelen, P., Christoffel, V., Spengler, B., Wuttke, W.
Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP. Phytomedicine, in press, 2005

Seidlová-Wuttke, H. Jarry, D., Pitzel, L., Wuttke, W.
Effects of estradiol-17ß, testosterone and a Black Cohosh preparation on bone and prostate in orchidectomized rats. Maturitas, in press, 2005

Seidlová-Wuttke, H. Jarry, D., Pitzel, L., Wuttke, W.
Effects of estradiol-17ß, testosterone and a Black Cohosh preparation on bone and prostate in orchidectomized rats. Maturitas, in press, 2004

Seidlová-Wuttke, D., Hesse, O., Jarry, H., Rimoldi, G., Thelen, P., Christoffel, V., W. Wuttke
Belamcanda chinensis and the thereof purified tectorigenin have selective estrogen receptor modulator activities. Phytomedicine 11.392-403, 2004

Thelen, P., Wuttke, W., Jarry, H., Grzmil M, Ringert, R-H.
Inhibition of telomerase activity and secretion of prostate-specific antigen by silibinin in prostate cancer cells. J Urol 171:1934-1938, 2004

Thelen, P., Jarry, H., Ringert, R-H., Wuttke, W.
Silibinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells. Planta Med 70:397-400, 2004

Wuttke, W., Jarry, H., Christoffel, V., Spengler, B., Seidlová.Wuttke, D.
Chaste tree (Vitex Agnus-castus) – Pharmacology and clinical indications. Phytomedicine, 10:348-357, 2003

Jarry, H., Metten, M., Wuttke, W., Spengler, B., Christoffel, V.
In vitro effects of the Cimicifuga racemosa extract BNO 1055. Maturitas 44: S31-38, 2003

Jarry, H., Spengler, B., Porzel, A., Schmidt, J., Wuttke, W., Christoffel, V.
Evidence for estrogen receptor ß-selective activity of Vitex Agnus castus and isolated flavones. Planta Medica 69: 945-947, 2003

Seidlová-Wuttke, D., Becker, T., Christoffel, V., Jarry, H., Wuttke, W.
Silymarin is a selective estrogen receptor ß (ERß) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomiezed (ovx) rats. J Steroid Biochem Mol Biol 86:179-188, 2003

Seidlová-Wuttke, D., Hesse, O., Jarry, H., Christoffel, V., Spengler, B., Becker, T., Wuttke, W.
Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17ß. Eur J Endocrinol 149:351-362, 2003

Seidlová-Wuttke, D., Jarry, H., Becker, T., Christoffel, V., Wuttke, W.
Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. Maturitas  44:S39-50, 2003

Wuttke, W., Seidlová-Wuttke, D., Gorkow, C..
The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 44:S67-77, 2003

Wuttke, W., Jarry, H., Becker, T., Schultens, A., Christoffel, V., Gorkow, C.,  Seidlová-Wuttke, D.
Phytoestrogens: Endocrine disrupters or replacement for hormone replacement therapy? Maturitas 44:S9-20, 2003

Wuttke, W., Seidlová-Wuttke, D., Balzer, I., Becker, T., Heiden, I., Jarry, H., Christoffel, V.
Phytoestrogens: dangerous drugs or soft hormones? In: Menopause: The State of the Art – in research and management. Ed. H.P.G. Schneider, Parthenon Publishing, pp. 295-306, 2003

Wuttke, W., Jarry, H., Westphalen, S., Christoffel, V., Seidlová-Wuttke, D.
Phytoestrogens for hormone replacement therapy? J Steroid Biochem Mol Biol 83:1-5, 2002

 

Neuroendokrinologie

Nicolas Lang1,2, Holger Rothkegel1,2, Heidi Reiber2, Alkomiet Hasan2, Elke Sueske2, Frithjof Tergau2, Hannelore Ehrenreich4, Wolfgang Wuttke3, Walter Paulus2
Circadian changes of GABA-mediated cortical inhibition. subm to Biolog Psych, 4/2010

T.A. Roepke1*, M.A. Bosch1*, E.A. Rick1, B. Lee4, E.J. Wagner4, D. Seidlova-Wuttke5, W. Wuttke512 , T.S.Scanlan1, O.K. Rønnekleiv1,2,3 and M.J. Kelly1
Contribution of the membrane estrogen receptor to the estrogenic regulation of bodytemperature and energy homeostasis. Endocrinology 2010

Claire J Herzog, Boldizsár Czéh, Silke Corbach, Wolfgang Wuttke,
Olaf Schulte-Herbrüggen, Rainer Hellweg, Gabriele Flügge and Eberhard Fuchs
Long term social instability stress in female rats: Effect on behaviour, body temperature and endocrine parameters. Neuroscience, 2008 accepted

Böttner M, Christoffel J, Wuttke W
Effects of long-term treatment with 8-prenylnaringenin and oral estradiol on the GH-IGF-1 axis and lipid metabolism in rats. J Endocrinol. 2008 Aug;198(2):395-401

Rachon D, Vortherms T, Seidlova-Wuttke D, Wuttke W,
Effects of dietary equol on the pituitary of the ovariectomized rats, Hormone and Metabolic Research, 39:256-61, 2007, PMID: 17447162

Happe S, Tings T, Koch W, Welsch J, Helmschmied K, Baier PC, Meller J, Wuttke W, Paulus W, Tatsch K, Trenkwalder C
Growth-hormone response in low-dose apomorphine test correlates with nigrostriatal dopmanine transporter binding in patients with Parkinson’s disease. J Neural Transm, 114(5): 589-94, 2007

Happe, S, Bachmann CG, Helmschmied K, Neubert, K, Wuttke W, Paulus W, Trenkwalder C
Growth hormone response to low-dose apomorphine in restless legs syndrome. Growth Horm IGF Res. 17(4): 323-327, 2007

Böttner M, Leonhardt S, Wuttke W, Jarry H,
Changes of expression of genes related to the activity of the gonadotropin-releasing hormone pulse generator in young versus middle-aged male rats. J Neuroendocrinol, 19(10): 779-87

Martina Böttner, Wolfgang Wuttke
Chronic treatment with physiological doses of estradiol affects the GH-IGF-I axis and fat metabolism in young and middled-aged ovariectomized rats, Biogerontology 7:91-100, 2006

Svenja Happe, Cornelius Bachmann, Kathrin Helmschmied, Karin Neubert, Wolfgang Wuttke, Walter Paulus, Claudia Trenkwalder,
Lack of evidence for increased hypothalamic dopaminergic receptor sensitivity in restless legs syndrome, submitted to Neurology, 2006

Martina Böttner, Wolfgang Wuttke
Chronic treatment with low doses of estradiol affects the GH-IGF-I axis and liver metabolism in young and middled-aged ovariectomized rats, Biogerontology 6:261-269, 2005

Roth, C., Hegemann, F., Hildebrandt, J., Balzer, I., Witt, A., Wuttke, W., Jarry, H.
Pituitary and gonadal efects of GnRH (gonadotropin releasing hormone) analogues in two peripubertal female rat models. Pediatr Res 55:126-133, 2004

Jarry, H., Metten, M., Gamer, A.O., Wuttke, W.
Effects of 5-day styrene inhalation on serum prolactin and dopamine levels and on hypothalamic and striatal catecholamine concentrations in male rats. Archives in Toxicology 76:657-663, 2002

Moguilevsky JA, Wuttke W.
Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats. Exp Clin Endocrinol Diabetes. 2001;109(4):188-95. Review.

Roth C, Schricker M, Lakomek M, Strege A, Heiden I, Luft H, Munzel U, Wuttke W, Jarry H.
Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model. J Endocrinol. 2001 May;169(2):361-71.

Han J, Seong JY, Kim K, Wuttke W, Jarry H.
Analysis of exonic splicing enhancers in the mouse gonadotropin-releasing hormone (GnRH) gene. Mol Cell Endocrinol. 2001 Feb 28;173(1-2):157-66.

Roth C, Schmidberger H, Lakomek M, Witt O, Wuttke W, Jarry H.
Reduction of gamma-aminobutyric acid-ergic neurotransmission as a putative mechanism of radiation induced activation of the gonadotropin releasing-hormone-pulse generator leading to precocious puberty in female rats. Neurosci Lett. 2001 Jan 5;297(1):45-8.

Roth C, Leonhardt S, Seidel C, Luft H, Wuttke W, Jarry H.
Comparative analysis of different puberty inhibiting mechanisms of two GnRH agonists and the GnRH antagonist cetrorelix using a female rat model. Pediatr Res. 2000 Oct;48(4):468-74.

 

Ovarforschung

Wuttke, W., Hinney, B.
Störung der weiblichen Gonaden, Medizinische Therapie 2007/2008, 3. Auflage, S. 690-716, 2007

Wuttke W, Pitzel L, Seidlova-Wuttke D, Hinney B.
LH pulses and the corpus luteum: the luteal phase deficiency LPD).
Vitam Horm. 2001;63:131-58. Review.

Pitzel L, Ludemann S, Wuttke W.
Secretion and gene expression of metalloproteinases and gene expression of their inhibitors in porcine corpora lutea at different stages of the luteal phase. Biol Reprod. 2000 May;62(5):1121-7.

Hirsch B, Knoke I, Leonhardt S, Pitzel L, Jarry H, Wuttke W.
Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak. Eur J Endocrinol. 1999 Jun;140(6):583-9.

Wuttke W, Spiess S, Knoke I, Pitzel L, Leonhardt S, Jarry H. Synergistic effects of prostaglandin F2alpha and tumor necrosis factor to induce luteolysis in the pig. Biol Reprod. 1998 May;58(5):1310-5.

 

Klinische Forschung

Wuttke W, Jarry H, Seidlova-Wuttke D.
(2009)
: Plant-derived alternative treatments for the aging male: facts and myths. Aging male . Epub ahead of print

W. Wuttke.
Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy? Maturitas 61 (2008) 159-170

Wuttke W.
Food supplementation products. Soya: more risks than benefits? MMW Fortschr Med. 2008 Jan 17;150(1-2):21. German.

W. Wuttke.
Kontra. Gynäkologie und Geburtshilfe 4-2008

Wolfgang Wuttke.
Soja: mehr Risiken als Nutzen? Gyn. und Geburtshilfe, 1-2008

W. Wuttke.
Nahrungsergänzungsmittel; Soja: mehr Risiken als Nutzen? MMW, Fortschritte der Medizin, Nr. 1-2/2008 (150. Jg.)

Thelen P, Burfeind P, Schweyer S, Scharf JG, Wuttke W, Ringert RH.
Molecular principles of alternative approaches for hormone-refractory prostate cancer. Urologie, 2007 46(9): 1271-4

Wuttke, W., Jarry, H., Seidlova´-Wuttke, D.
Isoflavones—Safe food additives or dangerous drugs?, Ageing Research Reviews 6, 150–188, 2007, Epub ahead of print

Wuttke W, Jarry H, Seidlová-Wuttke D.
(2006): Cimicifuga racemosa extract for the treatment of climacteric complaints. J Endoc Reprod (India), 10, 2,106-110.

Wuttke W, Rimoldi G, Christoffel J, Seidlová-Wuttke D.
(2006): Plant extracts for the treatment of menopausal women: safe? Maturitas supplement, 55S, 92-100.

Seidlová-Wuttke D, Pitzel L, Thelen P, Wuttke W.
(2006): Inhibition of 5a-reductase in the rat prostate by Cimicifuga racemosa. Maturitas Supplement, 55S, 75-82.

Thelen P, Seseke F, Ringert RH, Wuttke W, Seidlova-Wuttke D.
(2006):
Pharmacological potential of phytoestrogens in the treatment of prostate cancer, Urologie , 45(2), 195-6.

W. Wuttke und D. Seidlová-Wuttke
Phytoöstrogene und Altern. Jubiläumsband: EinVierteljahrhundert Frauenheilkunde und Geburtshilfe aus Münsteraner Sicht, August 2004, Münster

Boschitsch E, Skarabis H, Wuttke W, Heithecker R.
The acceptability of a novel oral contraceptive containing drospirenone and its effect on well-being. Eur J Contracept Reprod Health Care. 2000 Dec;5 Suppl 3:34-40.

 Blode H, Wuttke W, Loock W, Roll G, Heithecker R.
 A 1-year pharmacokinetic investigation of a novel oral contraceptive containing drospirenone in healthy female volunteers. Eur J Contracept Reprod Health Care. 2000 Dec;5(4):256-64.

Huber J, Foidart JM, Wuttke W, Merki-Feld GS, The HS, Gerlinger C, Schellschmidt I, Heithecker R.
Efficacy and tolerability of a monophasic oral contraceptive containing ethinylestradiol and drospirenone. Eur J Contracept Reprod Health Care. 2000 Mar;5(1):25-34.

Rosenbaum P, Schmidt W, Helmerhorst FM, Wuttke W, Rossmanith W, Freundl F, Thomas K, Grillo M, Wolf A, Heithecker R.
Inhibition of ovulation by a novel progestogen (drospirenone) alone or in combination with ethinylestradiol. Eur J Contracept Reprod Health Care. 2000 Mar;5(1):16-24.

 

Osteoporoseforschung

Kapur P, Wuttke W, Seidlova-Wuttke D.
(2010): Beneficial effects of ß-Ecdysone on joint, epiphyseal cartilage tissue and trabecular bone in ovarectomized rats. Phytomedicine, 17, 350-355

Sehmisch S, Dullin C, Zaroban A, Tezval M, Rack T, Schmelz U, Seidlova-Wuttke D, Dunkelberg H, Wuttke W, Marten K, Stuermer KM, Stuermer EK .
(2009)
: The use of flat panel volumetric computed tomography (fpVCT) in osteoporosis research. Academic Radiology, 16(4), 394-400.

Sehmisch S, Boeckhoff J, Wille J, Seidlova-Wuttke D, Rack T, Tezval M, Wuttke W, Stuermer KM, Stuermer EK (2009): Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation. Phytother Res., 23,851-858.

Sehmisch S, Dullin C, Zaroban A, Tezval M, Rack T, Schmelz U, Seidlova-Wuttke D, Dunkelberg H, Wuttke W, Marten K, Stuermer KM, Stuermer EK .
(2009)
: The use of flat panel volumetric computed tomography (fpVCT) in osteoporosis research. Academic Radiology, 16(4), 394-400

Sehmisch S, Hammer F, Christoffel J, Seidlová-Wuttke D, Tezval M,  Wuttke W, Stürmer KM,  Stürmer EK (2009): Comparison of the Phytohormone Genistein, Resveratrol and 8-Prenylnaringenin as Agents for Preventing Osteoporosis. Planta Medica, 74(8), 794-801.

Tezval M, Sehmisch S, Seidlová-Wuttke D, Rack T, Kolios L, Wuttke W, Stuermer KM, Stuermer EK.
(2010): Changes in the Histomorphometric and Biomechanical Properties of the Proximal Femur of Ovariectomized Rat after Treatment with the Phytoestrogens Genistein and Equol. Planta Medica, 76(3):235-40. 

Sehmisch S, Erren M, Rack T, Tezval M, Seidlova-Wuttke D, Richter J, Wuttke W. Stürmer K, Stürmer EK.
 (2009): Short-Term Effects of Parathyroid Hormone on Rat Lumbar Vertebrae. Spine, 34(19), 2014-21.

Stuermer EK, Sehmisch S, Tezval M, Tezval H, Rack T, Boekhoff J, Wuttke W, Hermann TR, Seidlova-Wuttke D, Stuermer KM.
(2009): Effect of testosterone and estrogen replacement on the microstructure and biomechanics of metaphyseal osteoporotic bones in orchidectomized male rats. World J Urol, 27(4), 547-555

Seidlová-Wuttke D, Jarry H, Jäger Y, Wuttke W.
(2008): Bone development in the female rats kept under soy-containing food as determined by computer tomography and by serum bone markers. Journal of Bone and Mineral Metabolism., 26(4), 321-327. 

Seidlová-Wuttke D, Schlumbohm C, Jarry H, Dullin C, Wuttke W.
Orchidectomized (orx) marmoset (Callithrix jacchus) as a model to study the development of osteopenia/osteoporosis. Am J Primatol. 2008 Mar;70(3):294-300.

S. Seidlová-Wuttke, K. Prelle, K.-H. Fritzemeier, W. Wuttke
Effects of estrogen receptor alpha- and beta-selective substances in the metaphysis of the tibia and on serum parameters of bone and fat tissue metabolism of ovariectomized rats. Bone.
 2008 Nov;43(5):849-55

Priya Kapur, H. Jarry, B.N Pereira, Dana Seidlová-Wuttke
Evaluation of the antiosteoporotic potential of Tinospora cordifolia in female rats. Maturitas 59 (2008)  329-38

Sehmisch S, dullin C, Zaroban A, Tezval M, Rack T, Schmelz U, Seidlova-Wuttke D, Dunkelberg H, Wuttke E, Marten K, Stuermer KM, Stuermer EK.
The use of flat panel volumetric computed tomography (fpVCT) in osteoporosis research. Acad Radiology 2008 Apr; 16(4):394-400

Sehmisch S, Boeckhoff J, Wille J, Seidlova-Wuttke D, Rack T, Tezval M, Wuttke W, Stuermer KM, Stuermer EK
Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation. Phytother Res. 2008 Dec 23.

Stuermer EK, Sehmisch S, Rack T, Wenda E, Seidlova-Wuttke D, Tezval M, Wuttke W, Frosch KH, Stuermer KM.
Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat. Langenbecks Arch Surg. 2008 Dec 2.

Stürmer EK., Seidlová-Wuttke D, Sehmisch S, Rack T, Wille J, Frosch KH, Wuttke W, Stürmer KM.
(2006): A standardized bending and breaking test for the normal and osteoporotic metaphyseal tibia of the rat. Effect of estrogen, testosterone and raloxifene.
J Bone Miner Res, 21, 89-96.